Healthy Brain Aging

- Preventing Mild Cognitive Impairment, Dementia, Neurodegeneration, Alzheimer's disease.

Novel Strategies for Healthy Brain Aging

One of the best strategies for healthy brain aging is regular aerobic exercise. As the world's population ages, the incidence of dementia and neurodegenerative diseases is expected to markedly increase. One key precursor to dementia and neurodegeneration is brain aging itself. Brain aging is characterized by declines in cognitive function (primarily memory and learning, attention/processing speed, and executive function). These declines may develop into mild cognitive impairment (MCI), which increases the risk for dementia and neurodegenerative diseases like Alzheimer's disease (AD).

Dysregulated Energy Metabolism: A Central Mechanism

Dysregulated energy metabolism is an underlying contributor to all hallmarks of brain aging. During aging, fasting glucose levels increase as cells become less effective at importing glucose in response to insulin (insulin resistance). Peripheral insulin resistance and elevated fasting glucose are linked with accelerated brain aging, poorer cognitive function, and dementia.

Exercise is perhaps the best strategy for inhibiting all major hallmarks of brain aging, largely because it activates key cellular energy-sensing pathways.

Exercise is an energetic stress (reduced cellular energy levels) that peripheral tissues and the brain react to with many metabolic, mitochondrial, and cellular responses (known as hormesis). These adaptive responses involve the activation of energy-sensitive pathways that restore bioenergetic homeostasis in both peripheral tissues and in the brain.

Mitochondrial Dysfunction

Aging is associated with a decline in efficiency of the electron transport chain, resulting in reduced ATP generation and electron leakage that propagates reactive oxygen species (ROS). These ROS can damage cellular structures, including mitochondria and even mitochondrial DNA (mtDNA). This mitochondrial dysfunction is a universal hallmark of aging that impairs overall tissue function, and it is exacerbated by age-related declines in mitochondrial biogenesis and disposal of damaged mitochondria (mitophagy).

Accumulation of Oxidatively Damaged Molecules

Oxidatively damaged biomolecules accumulate with aging as a result of oxidative stress, an imbalance between antioxidant defenses and ROS production.[3] These ROS can damage biomolecules like proteins, lipids, and DNA, as well as organelles — all of which can impair cellular function directly (because damaged components do not function properly) or indirectly (because damaged biomolecules may interfere with function in other cellular compartments). Neurons are especially sensitive to ROS because of their high, oxidizable lipid content and rate of oxidative metabolism.

Reduced Molecular Repair and Disposal

One main reason for both mitochondrial dysfunction and oxidative damage accumulation with aging is reduced activity of cellular repair and disposal systems.

Dysregulated Calcium Homeostasis

Cellular control of important ions and minerals becomes dysregulated in most aged tissues, but impaired calcium (Ca2+) homeostasis with aging is a particular problem in neurons. Ca2+ plays a role in numerous brain functions, including neurotransmission, neuronal excitability, synaptic plasticity, and long-term memory consolidation.

Impaired Adaptive Cellular Stress Response

All cells activate stress resistance networks (e.g., antioxidant and anti-inflammatory pathways) in response to stressors. In the brain, these adaptive responses are important in settings of electrochemical, ionic, and even psychological stress. With aging, however, most cells become markedly less effective at mounting adaptive stress responses.

Aberrant Neuronal Network Activity

The brain relies on communication among billions of neurons. Optimal function of neuronal networks requires balanced activity of glutamatergic (excitatory) neurons and GABAergic (inhibitory) interneurons. However, during aging, activity within these circuits (largely white matter communication via myelinated axons) is dysregulated, which can result in hyperexcitability and excitotoxic damage. This may lead to degeneration of fiber systems involved in decision making and learning/memory.

Inflammation

Neuroinflammation is characterized by increased numbers of immune-activated, proinflammatory astrocytes and microglia that secrete neurotoxic cytokines.[26] This glial cell activation is linked with brain aging, MCI, and most neurodegenerative diseases. In fact, markers of neuroinflammation and related neurodegeneration [e.g., glial fibrillary acidic protein (GFAP) and neurofilament light chain (NFL)] even have been shown to increase with aging in cognitively unimpaired people.[2] Evidence shows that exercise decreases brain inflammation, marked by lower levels of the proinflammatory transcription factor nuclear factor κB and tumor necrosis factor α (TNF-α), and that these changes are associated with improved spatial memory.

Impaired DNA Repair

The accumulation of DNA damage is an important hallmark of aging, and it plays a causal role in several premature aging syndromes. DNA damage also is closely linked with brain aging, cognitive decline, and neurodegenerative diseases.[8] The genomic damage that accumulates with aging can contribute to cellular senescence (in which cells cease dividing and begin to produce proinflammatory molecules) and apoptosis (programmed cell death), leading to functional decline of organs/systems (including the brain) and reduced longevity.

Impaired Neurogenesis/Stem Cell Exhaustion

Most neurons do not proliferate, but the dentate gyrus of the hippocampus, subventricular zone of the lateral ventricle, and the olfactory bulbs all contain stem cells.[41] As is the case with most stem cells, the ability of these stem cells to self-renew and generate new progenitors (neurogenesis) declines with aging, which may account for some of the structural declines observed in the aging brain.[8] However, exercise enhances neurogenesis within these areas.

Other: Telomere Attrition and Cellular Senescence

Telomeres are repetitive DNA sequences that cap the ends of chromosomes and protect DNA from degradation. They also protect overall cellular function, as critically short telomeres can lead to cell death or senescence. Telomere shortening and cellular senescence are established hallmarks of aging in peripheral tissues. Their role in brain aging is less clear, but telomere maintenance, which contributes to the production of neuronal stem cells, may protect against neurodegenerative diseases — and there is evidence that habitual exercise is associated with longer telomeres and reduced cellular senescence in both mice and humans.

Aerobic exercise clearly has a strong, inhibitory influence on all hallmarks of brain aging.

Exercise provides a strong physiologic/metabolic stimulus and it has been suggested that exercise should be a first-line strategy for healthy brain aging. Learn more here :

Ref : https://www.medscape.com/viewarticle/948940_1


Sinopharm COVID-19 & Latest Influenza Vaccines (Protects against Flu and H1N1 Viruses) / Pre-Departure COVID-19 PCR  Swab & Serology Tests for Travellers, Serology Testing to Certify Vaccination status and Pre-Event COVID Testing. Make your Appointment at Tel: 6694 1661

Flu Subsidy Scheme eligible for Singaporeans & PRs (Pay subsidized rate of $10 for Consultation and Treatment) & Merdeka Generation /Pioneer Generation seniors (Pay subsidized $5) for patients with Acute Respiratory Infections (ARIs).

Health Assessment & Screening Packages


Up to $400 per Medisave Account per year can be used for Vaccinations under the National Adult & Childhood Immunisation Schedule - Influenza, Pneumococcal (PCV13/PPSV), Human Papillomavirus (HPV2/HPV4), Hepatitis B, Tetanus, Diphtheria & Pertussis (Tdap), Measles, Mumps & Rubella (MMR) and Chickenpox (Varicella).

Part of MOH's Swab & Go Home programme. Our clinic can carry out the COVID-19 Swab test for anyone who meets the MOH medical criteria. All individuals aged 13 and above, diagnosed with ARI will be COVID Swab-tested. Cost of Swab test to be borne by Ministry of Health Singapore.

Part of the National Influenza Sentinel Surveillance programme with MOH. If you have a fever of > 38 degrees with a cough, our clinic is able to test for COVID-19. For children below 12 years old with clinical diagnosis of HFMD (eg fever, oral ulcers, rash), our clinic can test for Hand Foot & Mouth Disease (The tests are for surveillance purposes only).


MD International Medical Centre

Medical Services available :


Chiropractic Pain Management


Chiropractic Pain Management

Chiropractic Treatment

Non-invasive, Non-pharmacological Pain Management, Treatment for Radiculopathies (Nerve pain), Decreases Disease, Illness, Pains & Aches

Spinal Manipulation - Joints Issues

Shoulder – Frozen Shoulder/ Rotator Cuff Tear/ Impingement Syndrome, Elbow – Tennis Elbow/ Golf Elbow, Hip / Knee – Anterior Knee Pain/ Runner’s Knee/ Meniscus Injury/ Ligament Injury

Pain Management - Migraines & Headaches

Headaches/ Migraine/ Facial Palsy

Pain Management - Neck Pain

Neckaches/ Spondylosis/ Wry Neck/ Whiplash

Pain Management - Sports Injuries / Rib Issues

Athletic injuries - Tennis/Golfers Elbow(pain on the outside or inside of your elbow), Patella tendonitis/tendonosis (Jumpers Knee)

Pain Management - Ankle & Foot issues

Plantar Fasciitis/ Heel Pain/ Metatarsalgia

Pain Management - TMJ / Carpal Tunnel Issues

Pain Management - Back & Shoulder Pain

Back Strain/ Slipped Disc/ Scoliosis/ Sciatica/ Spondylosis/ Spondylolisthesis/ Spondylolysis, Shoulder impingement/Frozen shoulder

Better Posture & Movement

Posture issue – Scoliosis, Ligament – Sprains/ ACL Laxity/ Ankle Sprain, Muscle – Strains/ ITB Tightness/ Hamstring Tear Tendons – Tendonitis/ Repetitive Strain Injury/ Tendinopathy

Increased Wellness & Quality of Life

Joint Pain – Arthritis/ Cartilage Wear & Tear/ Osteoarthritis, Patellofemoral Knee pain (or pain at the front of the knee)

Improving Breathing / Sleep / Energy

Better Health, Happiness & Well-being Stress Management, Increased circulation, Reduced pain, Faster rehabilitation from injury, Increased lymphatic flow, Breaks up muscular scar tissue, Reduced lactic acid build up, Tissue Regeneration, Soft & Active tissue release

Fibromyalgia / Vertigo Management

Decrease anxiety, depression & prescription drug use

Post Operation/ Hospitalization

Improved Immune system & Strength Better life & Mobility

Obesity – Exercise & Meal Planning

Professional Chiropractic Equipment

DMS Professional Deep Muscle Stimulator Massager, Oceanus Shockwave Therapy - Physiotherapy, Rehabilitation, Orthopedics & Sports medicine

Non-invasive Chiropractic Treatment during Pregnancy

Effective Non-pharmacological way to alleviate pain from Sciatica. When something injures or puts pressure on the sciatic nerve, it can cause pain in the lower back that spreads to the hip, buttocks, and leg.


Healthy Aging


Public Health Preparedness Clinic

National University Health System Primary Care Network

Singapore Ministry of Health Chronic Disease Management Programme (CDMP)

The information provided in this website is for knowledge purposes only. It does not constitute medical advice.

Should you encounter any medical problem that you are unsure of, always consult your doctor or health care provider for assistance and medical advice.

MD International (Singapore) Pte Ltd

Enjoy this page? Please pay it forward. Here's how...

Would you prefer to share this page with others by linking to it?

  1. Click on the HTML link code below.
  2. Copy and paste it, adding a note of your own, into your blog, a Web page, forums, a blog comment, your Facebook account, or anywhere that someone would find this page valuable.
Share this page:

9 Taman Serasi #01-11, Botanic Gardens View

Tel : 65-6694-1661  Fax : 65-6694 1771

Email : contact@mdimc.sg

Clinic hours:

Monday to Friday: 9am-12.30pm / 2pm-6.30pm    Saturday: 9.30am-1pm

*Last registration is 30mins before the closing time

Closed on Sundays & Public Holidays

- Cashless service with most International Insurance companies and Insurance Medical cards are accepted

- Japanese & Mandarin-speaking Doctors and Medical staff

Please contact us at Tel: 6694 1661 to make an appointment.

OUR MEDICAL TEAM

Dr Don Lau – Medical Director

MBBS (Monash), B Med Sc (Hons) (Monash), Dip Pract Derm (Wales, UK)

Fujiwara Takanori

- Doctor of Chiropractic

The Chiropractic Association Singapore, Japan Chiropractic Register, American Chiropractic Association, California Chiropractic Association

Physiotherapy-trained NBCE The National Board of Chiropractic Examiners

Medical Conditions Treatable with Chiropractic:  

  • Head & Neck – Neckaches/ Spondylosis/ Wry Neck/ Whiplash/ Headaches/ Migraine/ Facial Palsy
  • Back – Back Strain/ Slipped Disc/ Scoliosis/ Sciatica/ Spondylosis/ Spondylolisthesis/ Spondylolysis
  • Shoulder – Frozen Shoulder/ Rotator Cuff Tear/ Impingement Syndrome
  • Elbow – Tennis Elbow/ Golf Elbow
  • Hip / Knee – Anterior Knee Pain/ Runner’s Knee/ Meniscus Injury/ Ligament Injury
  • Foot – Plantar Fasciitis/ Heel Pain/ Metatarsalgia
  • Joint – Arthritis/ Cartilage Wear & Tear/ Osteoarthritis
  • Ligament – Sprains/ ACL Laxity/ Ankle Sprain
  • Muscle – Strains/ ITB Tightness/ Hamstring Tear
  • Tendons – Tendonitis/ Repetitive Strain Injury/ Tendinopathy
  • Sports Injuries
  • Obesity – Exercise & Meal Planning 
  • Post Operation/ Hospitalization
  • Fibromyalgia

Dr Lee Sao Bing – Opthalmologist (in-house Specialist)

MBBS, MMed(Ophth), FRCSEd(Ophth), MD, FAMS

Dr Pang Yoke Teen – ENT (Visiting Consultant)

FRCS (ORL), FRCS(EDIN), (FRCSGLASG), FAMS, MBBS

MD International Medical Centre

Medical Services

Minor Surgical Procedures :

·       Injection for Supraspinatus or Bicipital Tendonitis / Epicondylitis / Trigger finger / Plantar Fasciitis

·       Tendon Sheath Injection

·       Excision of small Skin tumours / Lipomas / Nail bed / Ear lobe cysts / Meibomian cyst

·       Removal of Skin sutures / Skin tags / Sebaceous cysts / Various foreign bodies / Corneal foreign body

·       Liquid Nitrogen Therapy

·       Treatment of Plantar Warts / Calluses / Corns / Ganglions

·       Splinters under nails

·       Olecranon and Pre-patellar Bursitis

·       Ear syringing

·       Embedded earring stud

Recent Articles

  1. Allergy : Skin rash, Hay fever, Eczema, Hives and Bowel problems

    Oct 18, 21 06:22 AM

    Allergies are sensitive reactions that occur when the body’s immune system reacts in any unusual way to foods, airborne dust, animal hair, dust mites and pollens.

    Read More

  2. Chronic Neurological Disorders - Symptoms & Risks

    Oct 18, 21 06:18 AM

    Learn the Signs and Symptoms of Chronic Neurological Disorders. Seek medical attention as soon as possible if you are unsure of your medical condition.

    Read More

  3. What is Rheumatoid Arthritis? Is it a severe medical condition?

    Oct 18, 21 06:07 AM

    Rheumatoid arthritis is a disease of the joints, usually the smaller joints in the body. Not always a disabling condition, it can be controlled with medicine.

    Read More